Bioactivity:

TC-G 1005 is a potent and selective GPBA agonist (EC50 :0.72 nM; hTGR5). Selective for TGR5 over FXR (farnesoid X receptor). Increases plasma GLP-1 levels and reduces blood glucose in mice. Orally available.

CAS nr:

1415407-60-1

Purity:

98%

Molecular Weight:

399,49

SMILES:

O=C(N1CCN(C2CC2)C3=C1C=CC=C3)C4=C(OC5=CC(C)=CC=C5C)C=CN=C4

Formula:

C25H25N3O2

Pathway:

GPCR/G Protein

Target:

GPCR19