Bioactivity:

JHU395 delivers 6-diazo-5-oxo-L-norleucine (DON) to malignant peripheral nerve sheath tumor (MPNST) in vitro and in vivo, and has antitumor activity in MPNST. JHU395 is an orally-bioavailable and a plasma stable lipophilic glutamine antagonists (GA) prodr

CAS nr:

2079938-92-2

Purity:

98%

Molecular Weight:

447,48

SMILES:

O=C(C(C)(C)C)OC(OC(N[C@@H](CCC(C=[N+]=[N-])=O)C(OC(C)C)=O)=O)C1=CC=CC=C1

Formula:

C22H29N3O7

Pathway:

Tyrosine Kinase/Adaptors,Angiogenesis,JAK/STAT signaling

Target:

EGFR,EGFR,EGFR