Bioactivity:

SIAIS178 is a potent and selective degrader of BCR-ABL based on PROTAC technology (IC50 of 24 nM).

CAS nr:

2376047-73-1

Purity:

98%

Molecular Weight:

1012,68

SMILES:

O=C(N1CCN(C2=NC(C)=NC(NC3=NC=C(C(NC4=C(C=CC=C4Cl)C)=O)S3)=C2)CC1)CCCCCCC(N[C@@H](C(C)(C)C)C(N5[C@@H](C[C@@H](O)C5)C(NCC6=CC=C(C7=C(N=CS7)C)C=C6)=O)=O)=O

Formula:

C50H62ClN11O6S2

Pathway:

Others,Angiogenesis,Tyrosine Kinase/Adaptors,Cytoskeletal Signaling

Target:

Others,Bcr-Abl,Bcr-Abl,Bcr-Abl