Bioactivity:

Tazemetostat trihydrochloride is a selective and orally available inhibitor of EZH2 (IC50: 4 nM for rat EZH2). It inhibits the activity of human PRC2-containing wild-type EZH2 (Ki: 2.5 nM). It inhibits EZH2 (IC50s: 11 and 16 nM in peptide assay and nucleo

CAS nr:

1403255-00-4

Purity:

98%

Molecular Weight:

682,12

SMILES:

O=C(C1=CC(C2=CC=C(CN3CCOCC3)C=C2)=CC(N(CC)C4CCOCC4)=C1C)NCC5=C(C)C=C(C)NC5=O.[H]Cl.[H]Cl.[H]Cl

Formula:

C34H47Cl3N4O4

Pathway:

Chromatin/Epigenetic

Target:

Histone Methyltransferase