Bioactivity:

3-Deazauridine is a nucleoside analog. [1]? It is converted intracellularly to 3-deazauridine triphosphate, which competitively inhibits cytidine triphosphate synthetase thereby inhibiting biosynthesis of the nucleic acid cytidine 5�-triphosphate (CTP). 3-Deazauridine inhibits the growth of L1210 leukemia cells when used at a concentration of 6 µM and dose-dependently reduces mortality in a mouse model of leukemia.[2]? It also enhances the incorporation of decitabine into DNA in HL-60 myeloid and MOLT-3 lymphoid leukemia cells when used at a concentration of 20 µM. 3-Deazauridine (100 or 150 mg/kg), when combined with decitabine, reduces mortality in an L1210 leukemia mouse model.[3]

CAS nr:

23205-42-7

Purity:

98%

Molecular Weight:

243,215

SMILES:

OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1ccc(O)cc1=O

Formula:

C10H13NO6

Pathway:

Cell Cycle/Checkpoint,DNA Damage/DNA Repair

Target:

Nucleoside Antimetabolite/Analog,Nucleoside Antimetabolite/Analog