Bioactivity:

Fedratinib (TG101348) is an ATP-competitive inhibitor of JAK2 (IC50: 3 nM) with significantly less potent activity against JAK3.

CAS nr:

936091-26-8

Purity:

98%

Molecular Weight:

524,68

SMILES:

Cc1cnc(Nc2ccc(OCCN3CCCC3)cc2)nc1Nc1cccc(c1)S(=O)(=O)NC(C)(C)C

Formula:

C27H36N6O3S

Pathway:

Angiogenesis,Tyrosine Kinase/Adaptors,Apoptosis,Tyrosine Kinase/Adaptors,Stem Cells,Angiogenesis,JAK/STAT signaling,Chromatin/Epigenetic,Apoptosis

Target:

FLT,FLT,c-RET,c-RET,JAK,JAK,JAK,JAK,Apoptosis