Bioactivity:

PP-121 is a multi-targeted inhibitor of PDGFR (IC50: 2 nM), Hck (IC50: 8 nM), mTOR (IC50: 10 nM), VEGFR2(IC50: 12 nM), Src (IC50: 14 nM) and Abl (IC50: 18 nM) , also inhibits DNA-PK (IC50: 60 nM).

CAS nr:

1092788-83-4

Purity:

98%

Molecular Weight:

319,36

SMILES:

Nc1ncnc2c1c(nn2C1CCCC1)c1cnc2[nH]ccc2c1

Formula:

C17H17N7

Pathway:

Angiogenesis,Tyrosine Kinase/Adaptors,PI3K/Akt/mTOR signaling,Tyrosine Kinase/Adaptors,Angiogenesis,Tyrosine Kinase/Adaptors,Angiogenesis,Apoptosis,Angiogenesis,Tyrosine Kinase/Adaptors,Cytoskeletal Signaling,Tyrosine Kinase/Adaptors

Target:

PDGFR,PDGFR,mTOR,VEGFR,VEGFR,Src,Src,Apoptosis,Bcr-Abl,Bcr-Abl,Bcr-Abl,Hck