Bioactivity:

KU-0060648 is a dual inhibitor of DNA-PK and PI3K_, PI3K_, PI3K_ with IC50 of 8.6 nM and 4 nM, 0.5 nM, 0.1 nM respectively, less inhibition of PI3K_ with IC50 of 0.59 _M.

CAS nr:

881375-00-4

Purity:

98%

Molecular Weight:

582,71

SMILES:

CCN1CCN(CC1)CC(=O)NC2=C3C4=CC=CC=C4SC3=C(C=C2)C5=CC=CC6=C5OC(=CC6=O)N7CCOCC7

Formula:

C33H34N4O4S

Pathway:

PI3K/Akt/mTOR signaling,PI3K/Akt/mTOR signaling,PI3K/Akt/mTOR signaling,DNA Damage/DNA Repair

Target:

mTOR,PI3K,DNA-PK,DNA-PK