Tanzisertib M22926
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Specifications
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CAS Number:
899805-25-5
Target:
JNK
Molecular formula:
C21H23F3N6O2
Formula weight:
448,44
Purity:
>98% (HPLC)
Stability:
≥ 2 years
Product description:
Tanzisertib (CC-930) is a potent inhibitor of JNK1/2/3 with IC50s of 61/7/6 nM, respectively, with potential antifibrotic activity.Tanzisertib (CC-930) inhibits the formation of phospho-cJun in human PBMC stimulated by phorbol-12-myristate-13-acetate and phytohemeagglutinin (IC50=1 μM)[1] and it blocks the JNK pathway that is activated by pro-fibrotic cytokines in systemic sclerosis.
Note:
Research use only, not for human use.
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