A-674563 2HCl(552325-73-2(fb-2hcl)) M22765
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Specifications
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CAS Number:
——
Target:
Akt
Molecular formula:
C22H24Cl2N4O
Formula weight:
431,36
Purity:
>98% (HPLC)
Stability:
≥ 2 years
Product description:
A-674563 is an Akt1 inhibitor with Ki of 11 nM, modest potent to PKA and >30-fold selective for Akt1 over PKC.A-674563 reduces phosphorylation of Akt downstream targets in cells and slows proliferation of tumor cells in vitro (EC50: 0.4 μM) [1]. A563 (0-10 μM) markedly decreases GSK3 and MDM2 phosphorylation in STS cells.
Note:
Research use only, not for human use.
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