BOT-64 M22729
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Specifications
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CAS Number:
113760-29-5
Target:
IκB/IKK
Molecular formula:
C15H15NO2S
Formula weight:
273,35
Purity:
>98% (HPLC)
Stability:
≥ 2 years
Product description:
BOT-64 is an IKK-2 inhibitor which targets the Ser177 and/or Ser181 residues in the kinase's activation loop domain.BOT-64 is a cell-permeable benzoxathiole compoundBOT-64 inhibits IKKbeta-mediated IkappaBalpha phosphorylation in LPS-activated macrophages, resulting in sequential prevention of downstream events, including proteolytic degradation of IkappaBalpha, DNA binding ability, and transcriptional activity of NF-kappaB.
Note:
Research use only, not for human use.
More info:
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