J-113863 M22691
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Specifications
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CAS Number:
353791-85-2
Target:
CCR
Molecular formula:
C30H37Cl2IN2O2
Formula weight:
655.44
Purity:
>98% (HPLC)
Stability:
≥ 2 years
Product description:
J-113863 is also a potent antagonist of the human CCR3 (IC50 of 0.58 nM) , but a weak antagonist of the mouse CCR3 (IC50 of 460 nM). J-113863 is inactive against CCR2, CCR4 and CCR5, as well as the LTB4 or TNF-α receptors. Anti-inflammatory effect. J-113863 is a potent and selective CCR1 (CD18) antagonist with IC50 values of 0.9 nM and 5.8 nM for human and mouse CCR1 receptors, respectively.
Note:
Research use only, not for human use.
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