SAR-020106 M22629

CAS Number:

1184843-57-9

Target:

Chk

Molecular formula:

C19H19ClN6O

Formula weight:

382.85

Purity:

>98% (HPLC)

Stability:

≥ 2 years

Product description:

SAR-020106 is a potent, ATP-competitive, and selective CHK1 inhibitor with an IC50 of 13.3 nmol/L on the isolated human enzyme.SAR-020106 is an ATP-competitive, potent, and selective CHK1 inhibitor with an IC(50) of 13.3 nmol/L on the isolated human enzyme. This compound abrogates an etoposide-induced G(2) arrest with an IC(50) of 55 nmol/L in HT29 cells, and significantly enhances the cell killing of gemcitabine and SN38 by 3.0- to 29-fold in several colon tumor lines in vitro and in a p53-dependent fashion.

Note:

Research use only, not for human use.

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