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ML-180 M22607



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Specifications

inquiry

CAS Number:

863588-32-3

Target:

Other Targets

Molecular formula:

C20H25ClN4O2

Formula weight:

388.89

Purity:

>98% (HPLC)

Stability:

≥ 2 years

Product description:

ML-180 is a potent orphan nuclear receptor liver receptor homolog 1 (LRH-1; NR5A2) inverse agonist (IC50 of 3.7 µM) .ML-180 (0.5-5 µM; 24 hours) shows a significant inhibition of cyclin-D1 and cyclin-E1 expression in hepatic cells, but has little effect on repression in SK-OV-3 cells[2]. ML-180 (5 µM; 24 hours) leads to a rapid decrease of LRH-1 expression and efficiently represses endogenous LRH-1 signaling.

Note:

Research use only, not for human use.

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