MYCi975 M22558
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Specifications
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CAS Number:
2289691-01-4
Target:
c-Myc
Molecular formula:
C25H16Cl2F6N2O2
Formula weight:
561,3
Purity:
>98% (HPLC)
Stability:
≥ 2 years
Product description:
MYCi975 is an orally active inhibitor of MYC.MYCi975 inhibits P493-6, MV411,SK-N-B2 cells viability in an MYC-dependent manner(IC50s of 3.7, 3.9, 6.4 μM, respectively).The initial lead, MYC inhibitor 361 (MYCi361), suppressed in vivo tumor growth in mice, increased tumor immune cell infiltration, upregulated PD-L1 on tumors, and sensitized tumors to anti-PD1 immunotherapy. However, 361 demonstrated a narrow therapeutic index.
Note:
Research use only, not for human use.
More info:
Email info@sobekbio.com
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