UT-34 M22452
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Specifications
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CAS Number:
2168525-92-4
Target:
Androgen Receptor
Molecular formula:
C15H12F4N4O2
Formula weight:
356,27
Purity:
>98% (HPLC)
Stability:
≥ 2 years
Product description:
UT-34 is a selective and orally active antagonist of second-generation pan-androgen receptor (AR) and degrader(IC50s of 211.7 nM, 262.4 nM and 215.7 nM for wild-type, F876L and W741L AR, respectively), and has anti-prostate cancer efficacy. In LNCaP cells, UT-34 (3-10 µM; 24 hours) treatment inhibits the expression of PSA and FKBP5 and growth of LNCaP cells starting from 100 nM with maximum effect observed at 10 μM.
Note:
Research use only, not for human use.
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