Basimglurant M22362
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Specifications
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CAS Number:
802906-73-6
Target:
GluR
Molecular formula:
C18H13ClFN3
Formula weight:
325,77
Purity:
>98% (HPLC)
Stability:
≥ 2 years
Product description:
Basimglurant is a potent, selective and orally available modulator of mGlu5 negative allosteric(Kd of 1.1 nM). In competition binding experiments on human recombinant mGlu5, Basimglurant (RG7090) fully displaces [3H]-MPEP with a Ki of 35.6 nM and [3H]-ABP688 with a Ki of 1.4 nM. In HEK293 cells stably expressing human mGlu5, Basimglurant (RG7090) inhibits quisqualate induced Ca2+ mobilization with an IC50 of 7.0 nM and [3H]-inositolphosphate accumulation (IC50 of 5.9 nM).
Note:
Research use only, not for human use.
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