TH 5427 M16929
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Specifications
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CAS Number:
Target:
DNA Repair Protein
Molecular formula:
C20H20Cl2N8O3
Formula weight:
491,333
Purity:
>98% (HPLC)
Stability:
≥ 2 years
Product description:
TH 5427 (TH5427) is a potent, small molecule NUDT5 (NUDIX5) inhibitor with IC50 of 29 nM, 690-fold selectivity for NUDT5 over MTH1 (NUDT1) in vitro; shows little to no effect on NUDT9, dCTPase, NUDT12 and NUDT14; inhibits progestin-dependent nuclear ATP synthesis, subsequent chromatin remodeling, gene regulation and proliferation in breast cancer cells; a potent NUDT5 inhibitor that blocks hormone-dependent gene expression in breast cancer cells.
Note:
Research use only, not for human use.
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