Peficitinib M16761
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Specifications
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CAS Number:
944118-01-8
Target:
JAK
Molecular formula:
C18H22N4O2
Formula weight:
326,3929
Purity:
>98% (HPLC)
Stability:
≥ 2 years
Product description:
Peficitinib (ASP-015K, JNJ-54781532) is a potent JAK inhibitor with IC50s of 3.9 and 0.7 nM for JAK1 and JAK3 respectively; inhibits IL-2-dependent T cell proliferation in vitro and STAT5 phosphorylation in vitro and ex vivo; dose-dependently suppresses bone destruction and paw swelling in an adjuvant-induced arthritis model in rats; orally bioactive. Rheumatoid Arthritis Phase 3 Clinical
Note:
Research use only, not for human use.
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