R788 free base M16480
Specifications
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CAS Number:
901119-35-5
Target:
Syk
Molecular formula:
C23H26FN6O9P
Formula weight:
580,4595
Purity:
>98% (HPLC)
Stability:
≥ 2 years
Product description:
Fostamatinib (R788) is a prodrug of the active metabolite R406, which is a potent, ATP-competitive inhibitor of Syk kinase with Ki/IC50 of 30/41 nM; dose-dependently inhibits anti-IgE-mediated CHMC degranulation with an EC50 of 56 nM, inhibits all phosphorylation events downstream of Syk signaling; specifically inhibits FcγR signaling in human mast cells, macrophages, and neutrophils. R788 can inhibit local inflammatory injury mediated by immune complexes; reduces immune complex-mediated inflammation in arthritis models. Rheumatoid ArthritisPhase 3 Clinical
Note:
Research use only, not for human use.
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