AMG-548 M16264
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Specifications
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CAS Number:
864249-60-5
Target:
p38 MAPK
Molecular formula:
C29H27N5O
Formula weight:
461,569
Purity:
>98% (HPLC)
Stability:
≥ 2 years
Product description:
AMG-548 is a potent and selective inhibitor of p38α with Ki of 0.5 nM, dispalys weak inhibition for p38β (Ki=3.6 nM), and >5,000-fold selectivity over p38γ and p38δ; shows >1,000-fold selectivity over other 36 kinases, and is efficacious in acute and chronic models of arthritis. Rheumatoid ArthritisDiscontinued
Note:
Research use only, not for human use.
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