Tofacitinib citrate M14931
Specifications
| inquiry |
CAS Number:
540737-29-9
Target:
JAK
Molecular formula:
C22H28N6O8
Formula weight:
504,4931
Purity:
>98% (HPLC)
Stability:
≥ 2 years
Product description:
A potent, specific, orally active inhibitor of JAK3 with IC50 of 1 nM in cell-free assays; displays 20- to 100-fold less potency for JAK2 and JAK1 (IC50=20 nM and 112 nM, respectively), and shows no potent activity against 30 other kinases at >3 uM (CaMK1, ROCK2, Lck, MST2, etc.); effectively inhibits a murine mixed lymphocyte reaction (MLR) with IC50 of 91 nM, significantly prolonges survival in a murine model of heart transplantation and in cynomolgus monkeys receiving kidney transplants.Rheumatoid ArthritisApproved
Note:
Research use only, not for human use.
More info:
Email info@sobekbio.com
Orders:
Email orders@sobekbio.com