Tofacitinib M14592

CAS Number:

477600-75-2

Target:

JAK

Molecular formula:

C16H20N6O

Formula weight:

312,37

Purity:

>98% (HPLC)

Stability:

≥ 2 years

Product description:

Tofacitinib (CP-690550) is a potent, specific, orally active inhibitor of JAK3 with IC50 of 1 nM in cell-free assays; displays 20- to 100-fold less potency for JAK2 and JAK1 (IC50=20 nM and 112 nM, respectively), and shows no potent activity against 30 other kinases at >3 uM (CaMK1, ROCK2, Lck, MST2, etc.); effectively inhibits a murine mixed lymphocyte reaction (MLR) with IC50 of 91 nM, significantly prolonges survival in a murine model of heart transplantation and in cynomolgus monkeys receiving kidney transplants. Rheumatoid Arthritis Approved

Note:

Research use only, not for human use.

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