AZD-9056 hydrochloride M14179
Specifications
| inquiry |
CAS Number:
345303-91-5
Target:
P2X Receptor
Molecular formula:
C24H36Cl2N2O2
Formula weight:
455,46084
Purity:
>98% (HPLC)
Stability:
≥ 2 years
Product description:
A potent, selective, orally bioavailable P2X7 receptor antagonist; inhibits release of pro-inflammatory mediators from isolated human peripheral monocytes (IL-1β and IL-18) and human alveolar macrophages (IL-1β) with IC50 values of 10-13 nM; displays >100-fold selectivity and specificity other P2X receptors; also is an inhibitor of BCRP and weakly inhibited BCRP-mediated transport of methotrexate (IC50=92 uM); significantly reduces disease severity in the streptococcal cell wall (SCW) model of arthritis.Rheumatoid ArthritisPhase 2 Clinical
Note:
Research use only, not for human use.
More info:
Email info@sobekbio.com
Orders:
Email orders@sobekbio.com