NPS-2143 hydrochloride M14052
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Specifications
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CAS Number:
324523-20-8
Target:
CaSR
Molecular formula:
C24H26Cl2N2O2
Formula weight:
445,3814
Purity:
>98% (HPLC)
Stability:
≥ 2 years
Product description:
A potent, selective and orally active CaSR antagonist with IC50 of 43 nM; does not inhibit cytoplasmic Ca2+ responses to glutamate in HEK 293 cells engineered to express mGluRs and GABAB receptors; stimulates parathyroid hormone (PTH ) secretion from bovine parathyroid cells in vitro (EC50=39 nM) and increases plasma PTH levels in vivo; also inhibits lipopolysaccharide-induced pulmonary inflammation.OsteoporosisDiscontinued
Note:
Research use only, not for human use.
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