LSN 3213128 M13043
Specifications
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CAS Number:
1941211-99-9
Target:
Antifolate
Molecular formula:
C17H16FN3O4S2
Formula weight:
409,45
Purity:
>98% (HPLC)
Stability:
≥ 2 years
Product description:
LSN 3213128 is a novel potent, selective and orally-bioavailable antifolate with potent and specific inhibitory activity for AICARFT; results in dramatic elevation of 5-aminoimidazole 4-carboxamide ribonucleotide (ZMP) and growth inhibition in NCI-H460 and MDA-MB-231met2 cancer cell lines; demonstrates tumor growth inhibition in a murine based xenograft model of triple negative breast cancer (TNBC); Aminoimidazole-4-carboxamide ribonucleotide formyltransferase (AICARFT) is an enzyme in the purine biosynthetic pathway.
Note:
Research use only, not for human use.
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