P62-mediated mitophagy inducer M12772
Specifications
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CAS Number:
1809031-84-2
Target:
Mitophagy
Molecular formula:
C14H9IN4O2
Formula weight:
392,156
Purity:
>98% (HPLC)
Stability:
≥ 2 years
Product description:
P62-mediated mitophagy inducer (PMI) is a small molecule p62-mediated mitophagy inducer that activates mitophagy without recruiting Parkin or collapsing membrane potential and retains activity in cells devoid of a fully functional PINK1/Parkin pathway; induces doubling NQO1 activity at 1 uM, and upregulates Nrf2 and ARE-dependent antioxidant genes; increases the expression and signaling of the autophagic adaptor molecule P62/SQSTM1 and forces mitochondria into autophagy; disrupts the Nrf2-Keap1 interaction.
Note:
Research use only, not for human use.
More info:
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