PF-06651600 M12700
Specifications
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CAS Number:
1792180-81-4
Target:
JAK
Molecular formula:
C15H19N5O
Formula weight:
285,351
Purity:
>98% (HPLC)
Stability:
≥ 2 years
Product description:
PF-06651600 is a novel potent, selective JAK3 inhibitor with IC50 of 0.346 nM, displays >1,000-fold selectivity over JAK1 and JAK2; inhibits Th1 and Th17 cell differentiation and function, reduces disease pathology in rat adjuvant-induced arthritis as well as in mouse experimental autoimmune encephalomyelitis models; selectively targets γc cytokine pathways while preserving JAK1-dependent anti-inflammatory signaling such as the IL-10 suppressive functions following LPS treatment in macrophages and the suppression of TNFα and IL-1β production in IL-27-primed macrophages.Rheumatoid ArthritisPhase 2 Clinical
Note:
Research use only, not for human use.
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Email info@sobekbio.com
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