RN-486 M10978
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Specifications
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CAS Number:
1242156-23-5
Target:
BTK
Molecular formula:
C35H35FN6O3
Formula weight:
606,6892
Purity:
>98% (HPLC)
Stability:
≥ 2 years
Product description:
A potent and selective BTK inhibitor with IC50 of 4 nM in the enzymatic assay; shows high selectivity against a panel of 369 kinases; blocks Fcε receptor cross-linking-induced degranulation in mast cells (IC50=2.9 nM) and Fcγ receptor engagement-mediated TNFα production in monocytes (IC50=7.0 nM); robust anti-inflammatory and bone-protective effects in mouse CIA and rat adjuvant-induced arthritis (AIA) models.Rheumatoid ArthritisPreclinical
Note:
Research use only, not for human use.
More info:
Email info@sobekbio.com
Orders:
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