AVL-292 M10735
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Specifications
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CAS Number:
1202757-89-8
Target:
BTK
Molecular formula:
C22H22FN5O3
Formula weight:
423,4402
Purity:
>98% (HPLC)
Stability:
≥ 2 years
Product description:
AVL-292 (Spebrutinib, CC-292) is a highly selective, covalent Btk inhibitor with IC50 of <1 nM; also less potently inhibits Yes, c-Src, Brk, Lyn, and Fyn with IC50s of 723 nM, 1.729 uM, 2.43 uM, 4.4 uM, and 7.15 uM, rspectively; shows anti-inflammatory activity in the collagen-induced arthritis model of autoimmune disease; also prevents NRG- and EGF-dependent growth factor-driven resistance to lapatinib in HER2(+) breast cancer cells. Rheumatoid Arthritis Phase 2 Clinical
Note:
Research use only, not for human use.
More info:
Email info@sobekbio.com
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