T6167923 M10343
Specifications
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CAS Number:
1090528-71-4
Target:
MyD88
Molecular formula:
C17H20BrN3O3S2
Formula weight:
458,389
Purity:
>98% (HPLC)
Stability:
≥ 2 years
Product description:
T6167923 (T-6167923) is a small molecule inhibitor of MyD88-dependent signaling pathways, disrupts MyD88 homodimeric formation; inhibits SEB-induced inhibition of cytokine production in PBMCs with IC50 of 2-10 uM, also inhibits SEA-induced pro-inflammatory cytokine production, shows no toxicity in primary cells up to 100 uM; specifically inhibits TIR domain-mediated dimerization of full-length MyD88 as well as the recombinant TIR domain protein; dose-dependent in vivo therapeutic efficacy against SEB intoxication.
Note:
Research use only, not for human use.
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