Product overview:

Carrier-free (BSA/glycerol-free) CD137L mouse monoclonal antibody,clone LBI4G5

Field of research:

Cytokine-cytokine receptor interaction

Summary:

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction. [provided by RefSeq, Oct 2008]

Alternative names:

4-1BB-L; CD137L; TNLG5A

Species reactivity:

Human

Host:

Mouse

Target:

TNFSF9

Isotype:

IgG2b

Immunogen:

Full length human recombinant protein of human CD137L (NP_003802) produced in HEK293T cell.

Clone:

LBI4G5

Conjugation:

Unconjugated

Gene name:

Homo sapiens TNF superfamily member 9 (TNFSF9), mRNA.

Symbol:

TNFSF9

Pathway:

Cytokine-cytokine receptor interaction

Function:

Druggable Genome, Transmembrane

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

Form:

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Applications & dilution:

FLOW 1:100

Storage buffer:

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Storage:

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

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