Product overview:

Carrier-free (BSA/glycerol-free) MMP11 mouse monoclonal antibody,clone LBI3E10

Field of research:

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Summary:

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMP's, this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix. [provided by RefSeq, Jul 2008]

Alternative names:

SL-3; ST3; STMY3

Species reactivity:

Human

Host:

Mouse

Target:

MMP11

Isotype:

IgG1

Immunogen:

Human recombinant protein fragment corresponding to amino acids 239-488 of human MMP11 (NP_005931) produced in E.coli.

Clone:

LBI3E10

Conjugation:

Unconjugated

Gene name:

Homo sapiens matrix metallopeptidase 11 (MMP11), transcript variant 1, mRNA.

Symbol:

MMP11

Pathway:

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Function:

Druggable Genome, Protease

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

Form:

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Applications & dilution:

WB 1:500

Storage buffer:

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Storage:

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

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