Product overview:

Carrier-free (BSA/glycerol-free) OPTN mouse monoclonal antibody,clone LBI7H2

Field of research:

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Summary:

This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

Alternative names:

ALS12; FIP2; GLC1E; HIP7; HYPL; NRP; TFIIIA-INTP

Species reactivity:

Human

Host:

Mouse

Target:

OPTN

Isotype:

IgG1

Immunogen:

Full length human recombinant protein of human OPTN (NP_001008212) produced in HEK293T cell.

Clone:

LBI7H2

Conjugation:

Unconjugated

Gene name:

Homo sapiens optineurin (OPTN), transcript variant 1, mRNA.

Symbol:

OPTN

Pathway:

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Function:

Druggable Genome

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

Form:

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Applications & dilution:

WB 1:2000, IHC 1:500

Storage buffer:

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Storage:

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

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