Product overview:

Carrier-free (BSA/glycerol-free) MBD1 mouse monoclonal antibody,clone LBI1A1

Field of research:

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Summary:

The protein encoded by this gene is a member of a family of nuclear proteins related by the presence of a methyl-CpG binding domain (MBD). These proteins are capable of binding specifically to methylated DNA, and some members can also repress transcription from methylated gene promoters. This protein contains multiple domains: MBD at the N-terminus that functions both in binding to methylated DNA and in protein interactions; several CXXC-type zinc finger domains that mediate binding to non-methylated CpG dinucleotides; transcriptional repression domain (TRD) at the C-terminus that is involved in transcription repression and in protein interactions. Numerous alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011]

Alternative names:

CXXC3; PCM1; RFT

Species reactivity:

Human

Host:

Mouse

Target:

MBD1

Isotype:

IgG1

Immunogen:

Human recombinant protein fragment corresponding to amino acids 222-556 of human MBD1 (NP_056723) produced in E.coli.

Clone:

LBI1A1

Conjugation:

Unconjugated

Gene name:

Homo sapiens methyl-CpG binding domain protein 1 (MBD1), transcript variant 5, mRNA.

Symbol:

MBD1

Pathway:

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Function:

Druggable Genome, Transcription Factors

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

Form:

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Applications & dilution:

WB 1:200

Storage buffer:

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Storage:

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

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Orders:

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