Product overview:

Carrier-free (BSA/glycerol-free) SIRT1 mouse monoclonal antibody, clone LBI12H3

Field of research:

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Summary:

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]

Alternative names:

SIR2; SIR2alpha; SIR2L1

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

SIRT1

Isotype:

IgG2b

Immunogen:

Human recombinant protein fragment corresponding to amino acids 552-676 of human SIRT1(NP_036370) produced in E.coli.

Clone:

LBI12H3

Conjugation:

Unconjugated

Gene name:

Homo sapiens sirtuin 1 (SIRT1), transcript variant 1, mRNA.

Symbol:

SIRT1

Pathway:

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Function:

Druggable Genome, Stem cell - Pluripotency, Transcription Factors

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

Form:

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Applications & dilution:

WB 1:2000

Storage buffer:

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Storage:

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

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