Product overview:

Carrier-free (BSA/glycerol-free) OTX2 mouse monoclonal antibody,clone LBI1B2

Field of research:

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Summary:

This gene encodes a member of the bicoid subfamily of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and plays a role in brain, craniofacial, and sensory organ development. The encoded protein also influences the proliferation and differentiation of dopaminergic neuronal progenitor cells during mitosis. Mutations in this gene cause syndromic microphthalmia 5 (MCOPS5) and combined pituitary hormone deficiency 6 (CPHD6). This gene is also suspected of having an oncogenic role in medulloblastoma. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Pseudogenes of this gene are known to exist on chromosomes two and nine. [provided by RefSeq, Jul 2012]

Alternative names:

CPHD6; MCOPS5

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

OTX2

Isotype:

IgG1

Immunogen:

Full length human recombinant protein of human OTX2 (NP_068374) produced in E.coli.

Clone:

LBI1B2

Conjugation:

Unconjugated

Gene name:

Homo sapiens orthodenticle homeobox 2 (OTX2), transcript variant 1, mRNA.

Symbol:

OTX2

Pathway:

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Function:

Embryonic stem cells, Induced pluripotent stem cells, Stem cell - Pluripotency, Transcription Factors

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

Form:

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Applications & dilution:

WB 1:2000

Storage buffer:

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Storage:

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

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Orders:

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