Product overview:

Carrier-free (BSA/glycerol-free) PATZ1 mouse monoclonal antibody,clone LBI8D6

Field of research:

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Summary:

The protein encoded by this gene contains an A-T hook DNA binding motif which usually binds to other DNA binding structures to play an important role in chromatin modeling and transcription regulation. Its Poz domain is thought to function as a site for protein-protein interaction and is required for transcriptional repression, and the zinc-fingers comprise the DNA binding domain. Since the encoded protein has typical features of a transcription factor, it is postulated to be a repressor of gene expression. In small round cell sarcoma, this gene is fused to EWS by a small inversion of 22q, then the hybrid is thought to be translocated (t(1;22)(p36.1;q12). The rearrangement of chromosome 22 involves intron 8 of EWS and exon 1 of this gene creating a chimeric sequence containing the transactivation domain of EWS fused to zinc finger domain of this protein. This is a distinct example of an intra-chromosomal rearrangement of chromosome 22. Four alternatively spliced transcript variants are described for this gene. [provided by RefSeq, Jul 2008]

Alternative names:

dJ400N23; MAZR; PATZ; RIAZ; ZBTB19; ZNF278; ZSG

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

PATZ1

Isotype:

IgG1

Immunogen:

Full length human recombinant protein of human PATZ1(NP_114440) produced in E.coli.

Clone:

LBI8D6

Conjugation:

Unconjugated

Gene name:

Homo sapiens POZ/BTB and AT hook containing zinc finger 1 (PATZ1), transcript variant 4, mRNA.

Symbol:

PATZ1

Pathway:

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Function:

Transcription Factors

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

Form:

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Applications & dilution:

WB 1:2000

Storage buffer:

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Storage:

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

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Orders:

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