Product overview:

Carrier-free (BSA/glycerol-free) BLNK mouse monoclonal antibody, clone LBI4C9

Field of research:

B cell receptor signaling pathway, Primary immunodeficiency

Summary:

This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2012]

Alternative names:

AGM4; BASH; bca; BLNK-S; LY57; SLP-65; SLP65

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

BLNK

Isotype:

IgG2b

Immunogen:

Human recombinant protein fragment corresponding to amino acids 1-292 of human BLNK(NP_037446) produced in E.coli.

Clone:

LBI4C9

Conjugation:

Unconjugated

Gene name:

Homo sapiens B cell linker (BLNK), transcript variant 1, mRNA.

Symbol:

BLNK

Pathway:

B cell receptor signaling pathway, Primary immunodeficiency

Function:

Druggable Genome

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

Form:

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Applications & dilution:

WB 1:2000, IHC 1:150

Storage buffer:

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Storage:

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com