Product overview:

Carrier-free (BSA/glycerol-free) HDAC2 mouse monoclonal antibody, clone LBI7E10

Field of research:

Cell cycle, Chronic myeloid leukemia, Huntington's disease, Notch signaling pathway, Pathways in cancer

Summary:

This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes, and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). This protein forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus, it plays an important role in transcriptional regulation, cell cycle progression and developmental events. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]

Alternative names:

HD2; RPD3; YAF1

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

HDAC2

Isotype:

IgG1

Immunogen:

Human recombinant protein fragment corresponding to amino acids 415-488 of human HDAC2(NP_001518) produced in E.coli.

Clone:

LBI7E10

Conjugation:

Unconjugated

Gene name:

Homo sapiens histone deacetylase 2 (HDAC2), transcript variant 1, mRNA.

Symbol:

HDAC2

Pathway:

Cell cycle, Chronic myeloid leukemia, Huntington's disease, Notch signaling pathway, Pathways in cancer

Function:

Druggable Genome, Stem cell - Pluripotency, Transcription Factors

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

Form:

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Applications & dilution:

WB 1:2000, IHC 1:150

Storage buffer:

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Storage:

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com