Product overview:

Carrier-free (BSA/glycerol-free) CTLA4 mouse monoclonal antibody, clone LBI1E2

Field of research:

Autoimmune thyroid disease, Cell adhesion molecules (CAMs), T cell receptor signaling pathway

Summary:

This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq, Jul 2008]

Alternative names:

ALPS5; CD; CD152; CELIAC3; CTLA-4; GRD4; GSE; IDDM12

Species reactivity:

Human

Host:

Mouse

Target:

CTLA4

Isotype:

IgG1

Immunogen:

Full length human recombinant protein of human CTLA4 (NP_001032720) produced in HEK293T cell.

Clone:

LBI1E2

Conjugation:

Unconjugated

Gene name:

Homo sapiens cytotoxic T-lymphocyte associated protein 4 (CTLA4), transcript variant 2, mRNA.

Symbol:

CTLA4

Pathway:

Autoimmune thyroid disease, Cell adhesion molecules (CAMs), T cell receptor signaling pathway

Function:

Druggable Genome, Transmembrane

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

Form:

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Applications & dilution:

WB 1:2000

Storage buffer:

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Storage:

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com