Product overview:

Carrier-free (BSA/glycerol-free) MYBPC3 mouse monoclonal antibody, clone LBI2F8

Field of research:

Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM)

Summary:

MYBPC3 encodes the cardiac isoform of myosin-binding protein C. Myosin-binding protein C is a myosin-associated protein found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. MYBPC3, the cardiac isoform, is expressed exclussively in heart muscle. Regulatory phosphorylation of the cardiac isoform in vivo by cAMP-dependent protein kinase (PKA) upon adrenergic stimulation may be linked to modulation of cardiac contraction. Mutations in MYBPC3 are one cause of familial hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]

Alternative names:

CMD1MM; CMH4; cMyBP-C; FHC; LVNC10; MYBP-C

Species reactivity:

Human

Host:

Mouse

Target:

MYBPC3

Isotype:

IgG1

Immunogen:

Full length human recombinant protein of human MYBPC3（C0-C1） (NP_000247) produced in E.coli.

Clone:

LBI2F8

Conjugation:

Unconjugated

Gene name:

Homo sapiens myosin binding protein C3 (MYBPC3), mRNA.

Symbol:

MYBPC3

Pathway:

Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM)

Function:

Druggable Genome

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

Form:

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Applications & dilution:

ELISA 1:5000-10000

Storage buffer:

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Storage:

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com