Product overview:

Carrier-free (BSA/glycerol-free) PTCH1 mouse monoclonal antibody, clone LBI1H10

Field of research:

Basal cell carcinoma, Hedgehog signaling pathway, Pathways in cancer

Summary:

This gene encodes a member of the patched gene family. The encoded protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis, as well as the desert hedgehog and indian hedgehog proteins. This gene functions as a tumor suppressor. Mutations of this gene have been associated with basal cell nevus syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinomas of the bladder, as well as holoprosencephaly. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences and biological validity cannot be determined currently. [provided by RefSeq, Jul 2008]

Alternative names:

BCNS; HPE7; NBCCS; PTC; PTC1; PTCH; PTCH11

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

PTCH1

Isotype:

IgG1

Immunogen:

Human recombinant protein fragment corresponding to amino acids 770-1027 of human PTCH1 (NP_000255) produced in E.coli.

Clone:

LBI1H10

Conjugation:

Unconjugated

Gene name:

Homo sapiens patched 1 (PTCH1), transcript variant 1b, mRNA.

Symbol:

PTCH1

Pathway:

Basal cell carcinoma, Hedgehog signaling pathway, Pathways in cancer

Function:

Druggable Genome, ES Cell Differentiation/IPS, Transmembrane

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

Form:

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Applications & dilution:

WB 1:2000

Storage buffer:

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Storage:

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com