Product overview:

Carrier-free (BSA/glycerol-free) PDE1A mouse monoclonal antibody, clone LBI5H4

Field of research:

Calcium signaling pathway, Progesterone-mediated oocyte maturation, Purine metabolism, Taste transduction

Summary:

Cyclic nucleotide phosphodiesterases (PDEs) play a role in signal transduction by regulating intracellular cyclic nucleotide concentrations through hydrolysis of cAMP and/or cGMP to their respective nucleoside 5-prime monophosphates. Members of the PDE1 family, such as PDE1A, are Ca(2+)/calmodulin (see CALM1; MIM 114180)-dependent PDEs (CaM-PDEs) that are activated by calmodulin in the presence of Ca(2+) (Michibata et al., 2001 [PubMed 11342109]; Fidock et al., 2002 [PubMed 11747989]). [supplied by OMIM, Oct 2009]

Alternative names:

CAM-PDE-1A; HCAM-1; HCAM1; HSPDE1A

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

PDE1A

Isotype:

IgG2b

Immunogen:

Human recombinant protein fragment corresponding to amino acids 259-545 of human PDE1A (NP_005010) produced in E.coli.

Clone:

LBI5H4

Conjugation:

Unconjugated

Gene name:

Homo sapiens phosphodiesterase 1A (PDE1A), transcript variant 1, mRNA.

Symbol:

PDE1A

Pathway:

Calcium signaling pathway, Progesterone-mediated oocyte maturation, Purine metabolism, Taste transduction

Function:

Druggable Genome

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

Form:

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Applications & dilution:

WB 1:2000

Storage buffer:

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Storage:

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com