Product overview:

Carrier-free (BSA/glycerol-free) APP mouse monoclonal antibody, clone LBI4C9

Field of research:

Alzheimer's disease

Summary:

This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq]

Alternative names:

AAA; ABETA; ABPP; AD1; APPI; CTFgamma; CVAP; PN-II; PN2

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

APP

Isotype:

IgG2b

Immunogen:

Full length human recombinant protein of human APP(NP_000475) produced in HEK293T cell.

Clone:

LBI4C9

Conjugation:

Unconjugated

Gene name:

Homo sapiens amyloid beta precursor protein (APP), transcript variant 1, mRNA.

Symbol:

APP

Pathway:

Alzheimer's disease

Function:

Druggable Genome, Transmembrane

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

Form:

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Applications & dilution:

WB 1:2000, IHC 1:150

Storage buffer:

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Storage:

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com