Product overview:

Carrier-free (BSA/glycerol-free) MME mouse monoclonal antibody, clone LBI3D11

Field of research:

Alzheimer's disease, Hematopoietic cell lineage, Renin-angiotensin system

Summary:

This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5' untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts. The coding region is not affected by alternative splicing. [provided by RefSeq]

Alternative names:

CALLA; CD10; CMT2T; NEP; SCA43; SFE

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Target:

MME

Isotype:

IgG2a

Immunogen:

Full length human recombinant protein of human MME(NP_009218) produced in HEK293T cell.

Clone:

LBI3D11

Conjugation:

Unconjugated

Gene name:

Homo sapiens membrane metalloendopeptidase (MME), transcript variant 1bis, mRNA.

Symbol:

MME

Pathway:

Alzheimer's disease, Hematopoietic cell lineage, Renin-angiotensin system

Function:

Druggable Genome, Protease, Transmembrane

Purification:

Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Concentration:

Form:

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Applications & dilution:

WB 1:2000, IHC 1:150

Storage buffer:

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Storage:

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com