Product info:

This gene encodes a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Improper regulation of this gene is thought to be associated with several neurological disorders. Alternatively spliced transcript variants of this gene have been identified.

Alternative names:

SLC1A2; EAAT2; EIEE41; GLT-1; HBGT

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Cellular localisation:

Membrane, Multi-pass membrane protein

Isotype:

IgG

Immunogen:

Recombinant fusion protein containing a sequence corresponding to amino acids 495-574 of human EAAT2/EAAT2/SLC1A2 (NP_004162.2).

Positive control:

MCF7, HepG2, SW480, Mouse liver, Rat liver

AA Sequence:

HLSKSELDTIDSQHRVHEDIEMTKTQSIYDDMKNHRESNSNQCVYAAHNSVIVDECKVTLAANGKSADCSVEEEPWKREK

Purification:

Affinity purification

Molecular weight:

Calculated MW: 61kDa/62kDa Observed MW: 65kDa

Form:

Liquid

Applications:

WB (Rattus norvegicus, Mus musculus)

Dilution:

WB 1:500 - 1:5000 IHC 1:100 - 1:200

Storage buffer:

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:

Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

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