Product info:

This gene encodes a subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain. The protein is required for complex I assembly and electron transfer activity. The protein binds the signal transducers and activators of transcription 3 (STAT3) transcription factor, and can function as a tumor suppressor. The human protein purified from mitochondria migrates at approximately 16 kDa. Transcripts originating from an upstream promoter and capable of expressing a protein with a longer N-terminus have been found, but their biological validity has not been determined.

Alternative names:

NDUFA13; B16.6; CDA016; CGI-39; GRIM-19; GRIM19

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Cellular localisation:

Matrix side, Mitochondrion inner membrane, Nucleus, Single-pass membrane protein

Isotype:

IgG

Immunogen:

Recombinant fusion protein containing a sequence corresponding to amino acids 52-144 of human NDUFA13/GRIM19 (NP_057049.5).

Positive control:

293T, HepG2, MCF7, PC-3, Mouse brain, Mouse heart, Rat testis, Rat heart

AA Sequence:

KWNRERRRLQIEDFEARIALLPLLQAETDRRTLQMLRENLEEEAIIMKDVPDWKVGESVFHTTRWVPPLIGELYGLRTTEEALHASHGFMWYT

Purification:

Affinity purification

Molecular weight:

Calculated MW: 16kDa/24kDa Observed MW: 17KDa

Form:

Liquid

Applications:

WB (C2C12, Homo sapiens)

Dilution:

WB 1:500 - 1:2000

Storage buffer:

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:

Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

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