Product info:

Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. GPM6A-induced filopodia formation involves mitogen-activated protein kinase (MAPK and Src signaling pathways. May be involved in neuronal NGF-dependent Ca(2+ influx. May be involved in regulation of endocytosis and intracellular trafficking of G-protein-coupled receptors (GPCRs; enhances internalization and recycling of mu-type opioid receptor.

Alternative names:

GPM6A; GPM6; M6A

Species reactivity:

Mouse, Rat

Host:

Rabbit

Cellular localisation:

Cell membrane, Cell projection, Multi-pass membrane protein, axon, dendritic spine, filopodium

Isotype:

IgG

Immunogen:

Recombinant fusion protein containing a sequence corresponding to amino acids 159-278 of human GPM6A (NP_005268.1).

Positive control:

Mouse eye, Rat liver

AA Sequence:

WTICRNTTLVEGANLCLDLRQFGIVTIGEEKKICTVSENFLRMCESTELNMTFHLFIVALAGAGAAVIAMVHYLMVLSANWAYVKDACRMQKYEDIKSKEEQELHDIHSTRSKERLNAYT

Purification:

Affinity purification

Molecular weight:

Calculated MW: 29kDa/30kDa/31kDa Observed MW: 31kDa

Form:

Liquid

Applications:

Request info at info@sobekbio.com

Dilution:

WB 1:500 - 1:2000

Storage buffer:

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:

Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com