Product info:

Adapter protein involved in protein degradation by interacting with COP1 ubiquitin ligase. The COP1-binding motif is masked by autoinhibitory interactions with the protein kinase domain. Serves to alter COP1 substrate specificity by directing the activity of COP1 toward CEBPA. Binds selectively the recognition sequence of CEBPA. Regulates myeloid cell differentiation by altering the expression of CEBPA in a COP1-dependent manner (By similarity. Controls macrophage, eosinophil and neutrophil differentiation via the COP1-binding domain (By similarity. Interacts with MAPK kinases and regulates activation of MAP kinases, but has no kinase activity.

Alternative names:

TRIB1; C8FW; GIG-2; GIG2; SKIP1; TRB-1; TRB1

Species reactivity:

Human

Host:

Rabbit

Cellular localisation:

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Isotype:

IgG

Immunogen:

Recombinant fusion protein containing a sequence corresponding to amino acids 203-372 of human TRIB1 (NP_079471.1).

Positive control:

U-87MG, BxPC-3, Raji

AA Sequence:

LGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQFCIPEHISPKARCLIRSLLRREPSERLTAPEILLHPWFESVLEPGYIDSEIGTSDQIVPEYQEDSDISSFFC

Purification:

Affinity purification

Molecular weight:

Calculated MW: 23kDa/41kDa Observed MW: 38kDa

Form:

Liquid

Applications:

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Dilution:

WB 1:1000 - 1:4000

Storage buffer:

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:

Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

More info:

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Orders:

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